Dr Clarissa Naidoo, a Postdoctoral Researcher in the Department of Biology and Environmental Sciences at Sefako Makgatho Health Sciences University (SMU), is redefining the future of green nanotechnology. At the 2024 SMU Research Day, she was awarded first place in the postdoctoral research category for her groundbreaking work on the biosynthesis of silver nanoparticles (AgNPs) using Tabernaemontana ventricosa, a medicinal plant indigenous to South Africa. This innovative research positions Naidoo at the forefront of sustainable health solutions and reinforces SMU’s reputation as a leader in impactful scientific research.
Dr Clarissa Naidoo, Postdoctoral Researcher in the Department of Biology and Environmental Sciences at SMU
Naidoo’s research addresses the growing demand for nanoparticles in medical, agricultural, and environmental applications. Her work stands out for its novel approach to nanoparticle synthesis, using plant-based methods that are more environmentally friendly than conventional chemical processes. By leveraging the unique biochemical properties of T. ventricosa, Naidoo has developed a sustainable method for creating AgNPs, significantly reducing the environmental footprint typically associated with traditional synthesis techniques.
The application of advanced characterisation techniques such as Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray (EDX) analysis, and Fourier Transform Infrared (FTIR) spectroscopy confirmed the successful synthesis of AgNPs. The nanoparticles exhibited a diverse range of shapes, including spherical, ovate, and triangular, with sizes ranging from 16 to 80 nm. Importantly, they demonstrated exceptional stability—an essential feature for their potential therapeutic applications.
The bioactivity of the AgNPs was assessed, with promising results. The nanoparticles demonstrated significant antibacterial properties, effectively combating multiple bacterial strains, which can be attributed to the antimicrobial compounds naturally present in T. ventricosa. More strikingly, the research also revealed the cytotoxic potential of these nanoparticles, with an IC50 value of 0.39 μg/mL in inhibiting the growth of HeLa cancer cells. This suggests that the plant-derived AgNPs could serve as potent agents in cancer treatment, providing new possibilities for future oncological therapies.
Naidoo’s study represents the first documented instance of AgNP synthesis from T. ventricosa, marking a pivotal moment in the exploration of plant-derived nanoparticles. Her research opens exciting new avenues for antibacterial and anticancer applications and highlights the importance of selecting the right plant sources for nanoparticle synthesis. Furthermore, her findings lay the groundwork for future studies into the specific phytochemicals responsible for nanoparticle formation, which could enhance the efficacy and safety of plant-based therapies
This innovative research has far-reaching implications. Not only does it contribute to the field of nanotechnology, but it also advances the understanding of plant biochemistry and its potential applications in medicine. Naidoo’s work exemplifies SMU’s commitment to integrating cutting-edge science with environmental sustainability, positioning SMU as a hub for research that addresses pressing global challenges
The impact of Naidoo’s work extends beyond the realm of nanotechnology. By developing sustainable, bio-inspired solutions, she is advancing a new era of medical and environmental research. Her contributions underline the value of integrating scientific innovation with ecological responsibility—principles that are at the core of SMU’s broader research mission. Through her work, Naidoo is not only advancing health sciences but also helping to shape a future where sustainable, plant-based solutions play a central role in medicine
As SMU continues to make strides in research excellence, Naidoo’s achievements exemplify the university’s role in shaping the global scientific landscape. With a focus on innovative, eco-friendly solutions to health and environmental issues, her research enhances SMU’s reputation as a world-class institution for cutting-edge, socially responsible science.
Naidoo’s contributions also underscore SMU’s increasing prominence on the global research stage. As the university continues to foster excellence in research, particularly in health sciences and sustainability, the groundbreaking work of academics like Naidoo demonstrates SMU’s leadership in driving scientific innovation with real-world impact. Her research not only positions her as a leader in nanotechnology but also highlights SMU’s dedication to producing research that makes a meaningful difference in the world
Through such achievements, SMU continues to cement its place as a premier institution in health sciences, advancing both the local and global scientific communities with research that balances innovation with sustainability.
