Sefako Makgatho Health Sciences University (SMU) is strengthening its contribution to pharmaceutical research and innovation through the work of Dr Pedzisai Makoni, a Senior Lecturer in the Department of Pharmaceutical Sciences in the School of Pharmacy, whose research, postgraduate supervision and external scientific engagements are advancing the development of innovative drug-delivery systems.
A pharmacist and PhD-qualified pharmaceutical scientist, Dr Makoni is an NRF Y2-rated researcher, a recognition that signals his potential to establish himself as a leading researcher through the quality and trajectory of his recent research outputs. With more than 15 years of combined industrial, teaching and research experience, his work reflects SMU’s commitment to developing research capacity that responds to complex healthcare challenges.
His research focuses on formulating and developing novel dosage forms for targeted delivery of active pharmaceutical ingredients, with particular expertise in lipidic nanocarriers, pharmaceutical analysis, and characterisation. This includes using solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) to improve the delivery of poorly soluble medicines.
“Pharmaceutical sciences provide an important bridge between scientific discovery and improved healthcare. My research is focused on developing drug-delivery systems that can address practical challenges in medicine formulation while contributing to improved therapeutic outcomes,” said Dr Makoni.
His research portfolio includes investigations into lipid-based delivery systems for medicines with significant therapeutic applications. During his postgraduate research at Rhodes University, he investigated efavirenz-loaded lipid nanocarriers, which could improve medicine delivery while addressing challenges associated with antiretroviral therapy. His doctoral research examined clarithromycin-loaded lipid nanocarriers for potential use in treating non-tuberculous bacterial keratitis.
Since joining SMU in March 2024, Dr Makoni has also helped expand the University’s research infrastructure and collaborative research capacity. His research activities have attracted funding from several competitive programmes, including the National Research Foundation (NRF) Thuthuka Post-PhD Track and the SA/France PROTEA programme.
A significant achievement is his involvement as a co-user on an NRF National Equipment Programme grant valued at R10 million. The investment represents an important contribution to research infrastructure and could strengthen researchers’ capacity to undertake advanced scientific investigation and generate high-quality research outputs.
“Access to appropriate research infrastructure is critical to producing rigorous, competitive research. The R10 million equipment investment creates opportunities to strengthen analytical and research capabilities while supporting collaboration and the development of postgraduate researchers,” he said.
Beyond his research outputs, Dr Makoni is actively involved in postgraduate supervision, teaching and academic examination. He has supervised MSc, MPharm and PhD students, while also examining postgraduate theses across several South African and international-linked institutions. His academic responsibilities include teaching Pharmacology, Pharmaceutics and Pathophysiology to BPharm students.
His expertise also extends beyond the university. Since 2020, he has served as an external expert evaluator for the South African Health Products Regulatory Authority (SAHPRA) Pharmaceutical and Analytical Committee, contributing specialist knowledge to the evaluation of pharmaceutical products and regulatory matters. He has further participated in research collaborations and product reformulation projects with industry.
Dr Makoni’s growing research profile, competitive funding, postgraduate supervision and professional engagement collectively contribute to SMU’s vision of transforming health services through excellence and innovation. His work shows how research at the University can strengthen scientific capacity, develop future researchers, and contribute to solutions relevant to pharmaceutical development and healthcare delivery.
Through academics such as Dr Makoni, SMU continues to build a research-intensive health sciences environment where innovation, advanced training, and scientific collaboration contribute to the University’s broader impact on healthcare in South Africa and beyond.
By Tumelo Moila
