by Lorato | Jun 25, 2025 | Accolades and Achievements, All News, Alumni, SMU Media, Student Media
At the heart of SMU’s research strategy lies a commitment to interdisciplinary collaboration, knowledge generation, and technology transfer. By fostering innovation and expanding its research capacity, the university aims to play a pivotal role in addressing South Africa’s pressing healthcare challenges — from infectious diseases to mental health and non-communicable conditions.
A prime example of this ambition is the School of Pharmacy’s recent achievement: securing its second provisional patent. Dr Bwalya Witika, a senior lecturer in Pharmaceutics and his postdoctoral fellow, Dr Jean Ngilirabanga, who joined him in 2023, successfully filed a patent titled “Eutectic Compositions”, with the priority date of 9 June 2025. Their work explores novel drug delivery mechanisms by combining compounds to lower melting points, enhancing the efficacy and tolerability of treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs). This breakthrough reaffirms the school’s growing reputation for pharmaceutical innovation and research excellence.
Eutectic compositions are mixtures of substances that, when combined, melt at a temperature lower than either of the individual components. In pharmaceutical science, this characteristic is highly valuable for improving drug solubility, stability and delivery, two critical challenges in modern medicine. Witika traced the origins of this research back to 2022, inspired by the urgent need for safer pain management alternatives during the global opioid crisis. “NSAIDs weren’t enough, and opioids came with long-term risks. I wondered—what if we enhanced NSAIDs with something like chilli?” he explained, referring to Nonivamide, a compound structurally related to capsaicin.
The research process involved formulating innovative drug combinations that provided synergistic pain relief. Despite the scientific and administrative challenges, the work culminated in a promising invention that could reshape pain treatment approaches. While the research was conducted internally at SMU, Witika confirmed that discussions with potential industry partners are already underway. “For now, it’s been in-house, but the potential for wider collaboration is significant,” he said.
Filing a provisional patent provides legal protection while allowing further refinement of the invention. Witika praised SMU’s Technology Transfer Office (TTO) for its vital support throughout the process. “TTO Liaison Officer Pontsho Mampuru is a superhero, relentless in his commitment. It’s been a pleasure working with TTO,” he added.
This development follows SMU’s historic first patent in 2024: Raloxifene Hydrochloride Hydrate Solvate, a novel compound with the potential to revolutionise treatment for postmenopausal osteoporosis and breast cancer. That breakthrough was led by Emmanuel Kiyonga, a master’s graduate in the School of Pharmacy, and marked the beginning of a new era of innovation for the university.
Together, these patents underscore SMU’s transformation into a research-intensive health sciences institution committed to addressing global health challenges through science and invention. Witika and Ngilirabanga are optimistic about the future of their research. They believe their eutectic formulation could make a major impact on drug development, particularly in the field of pain management. Further patent filings and commercialisation efforts are already underway. “This is just the beginning,” said Witika. “We’re at the forefront of something meaningful. It’s vital that inventors maintain a connection to their work—we must ensure that identity is preserved in the products we create.”
For Witika, the success is both professional and deeply personal. “Even though this is my second patent, the feeling is just as incredible. You’re reminded that you’re contributing something small but significant.” His advice to fellow academics? “Go for it. Don’t hold back.”
For Ngilirabanga, this has been a great success. “I am immensely proud of this achievement, and I am excited about the future. This is my first patent, the first of many. To my fellow academics, keep pushing. Let’s make SMU proud,” said Ngilirabanga.
Looking ahead, they hope that this achievement—along with future innovations—will encourage university leadership to recognise and support the vital role of research in shaping a better world. “These are small steps,” he said, “but they’re paving the way for greater impact on science, patients, and future scholars.”
By Tumelo Moila
by Lorato | Jun 25, 2025 | Accolades and Achievements, All News, Alumni, SMU Media, Student Media
In a momentous achievement for Sefako Makgatho Health Sciences University (SMU), Professor Deliwe Rene Phetlhu, Head of the Department of Nursing Sciences, has been awarded the prestigious National Research Foundation (NRF)’s u’Good Grant to the value of R9.1 million. Her successful proposal, selected from over 200 global submissions, is one of only 22 awarded internationally and will fund a groundbreaking project titled “Youth Mental Health in the Era of Climate Change.”
Speaking on the announcement, Professor Phetlhu expressed her elation. “I was overjoyed, particularly because I will be working with young academics, some of whom have never worked on major grants before. Being selected among the top 22 worldwide is a significant honour.”
The three-year project (2025–2027) aims to develop a culturally responsive intervention to enhance the psychological resilience and well-being of young people in South Africa, Ghana, and Tanzania. The research will be grounded in the relational well-being (RWB) theory and principles of Ubuntu, integrating culture, socio-economic contexts, and environmental stressors into its approach.
“Personally, this award affirms my commitment to impactful research,” said Phetlhu. “Professionally, it highlights the critical role nurses can play in emerging areas of health sciences. As the first line of defence in healthcare, nurses are uniquely positioned to lead research that transcends traditional boundaries.”
The project will begin by investigating youth awareness, cultural narratives, and environmental anxieties linked to climate change, before developing and piloting a targeted intervention. Innovative methodologies such as photovoice and vignettes will be employed to capture lived experiences, while technologies like RedCap will ensure secure data handling.
Funding allocation reflects the project’s community-driven ethos. Equipment such as laptops, cameras, and audio recorders will be acquired early on, but the bulk of resources are earmarked for operational costs, particularly youth engagement and travel. Administrative support across the three countries is also a key consideration.
Each project year has clear milestones:
- 2025: Understanding youth climate awareness and mental health practices across three African contexts.
- 2026: Development of an integrated, culturally grounded intervention framework.
- 2027: Implementation of a scalable model for African youth mental health resilience, potentially redefining wellbeing from a continental perspective.
“This research is urgent,” Phetlhu explains. “Globally, climate change is a daily conversation, but in Africa, the link to mental health—especially among youth—is often overlooked. From funeral queues to community gatherings, I’ve asked people their thoughts, and the lack of awareness is concerning.”
The project is proudly transdisciplinary, involving youth-centred NGOs, sociologists, environmentalists, and educational psychologists from South Africa, Ghana, and Tanzania. SMU will host the lead PhD student and two master’s candidates in later stages, while early-career researchers from the institution are included as co-investigators.
The long-term goal is to influence youth mental health policy and practice. “Mental health is becoming a global pandemic. The next generation will carry the heaviest burden of climate change, and they must be equipped with resilience and leadership skills,” Phetlhu said.
She has already initiated engagement with government and sector stakeholders. “I don’t want them to only hear about the project at the end. Their involvement from the start is essential for sustainability.”
Prof Phetlhu also extended gratitude to the SMU Grants Office. “Ms Winnie Motsatsi was phenomenal, supporting me through every step, arranging a reviewer, and accommodating my schedule. I couldn’t have done it without her.”
To fellow researchers at SMU, Phetlhu had a message of inspiration: “Take a risk. Even if it doesn’t work the first time, it’s worth trying. Surround yourself with people who share your work ethic. It might just happen.”
As the project is currently underway, Phetlhu hopes to ignite a continental dialogue on youth wellbeing and climate resilience. “Africa’s future depends on it. Let us prepare our youth to carry the baton with strength and purpose.”
By Tumelo Moila
by Lorato | Jun 25, 2025 | Accolades and Achievements, All News, SMU Media, Student Media
At just 22 years old, Hermy Mantjiu is proving that hard work, curiosity, and resilience are a powerful combination. Hailing from Kalkspruit Ga-Maraba in Limpopo, Hermy recently graduated summa cum laude with a Bachelor of Science Honours in Statistics from Sefako Makgatho Health Sciences University (SMU). His remarkable academic journey reflects not only his brilliance but also his commitment to using mathematics to solve real-world problems.
Now an honours student working for the Department of Statistical Science, Mantjiu reflects proudly on his academic success. “It hasn’t always been easy,” he says, “but I’ve worked hard, stayed disciplined, and grown not just academically, but also personally. My achievements reflect my dedication and love for learning, especially in challenging subjects like mathematics and statistics.”
Inspired by Mason Cooley’s quote, “Procrastination makes easy things hard, hard things harder,” Mantjiu’s disciplined approach has guided him through the rigours of Mathematical Science — a field he describes as intellectually stimulating and deeply rewarding.
“I love how maths challenges me to think differently. It’s like solving a puzzle — sometimes frustrating, but incredibly satisfying when everything finally clicks,” he explains. Unlike traditional mathematics, which focuses largely on theory, Mathematical Science merges pure and applied maths with statistics, computing, and modelling. “That’s what makes it so versatile and relevant in today’s data-driven world,” he adds.
His programme covered a wide range of areas, including abstract algebra, applied mathematics, and statistics. While he admits that abstract algebra was particularly challenging, he grew to appreciate its elegance and structure. On the other hand, mathematics and statistics stood out as favourites, especially when applied to real-world scenarios.
Mantjiu’s Honours project, “Correlates of Reading Literacy Among Participants Aged 15–30: A Case Study of Four Provinces in South Africa”, demonstrated how statistics can directly inform decision-making in areas such as health, finance, and technology. “It showed me how statistics can directly support decision-making in health, finance, and technology,” he says.
His work wasn’t confined to theoretical exercises. Mantjiu became proficient in RStudio, Stata, and MATLAB, using them to simulate complex systems, solve differential equations, and analyse datasets. “These computational tools made our work more efficient and accurate,” he says. “We even solved differential equations using numerical methods like Euler and Runge-Kutta.”
Mantjiu’s passion for problem-solving extends into interdisciplinary fields such as data science and public health. He believes mathematical modelling plays a crucial role in addressing global issues like climate change, pandemics, and inequality. “Statistical inference, for example, helps us make informed decisions based on uncertain information — from clinical trials to financial forecasting,” he explains.
His success was not a solo journey. “My mentors and the students I tutored had a huge impact on my growth,” he shares. “Teaching others deepened my own understanding and kept me motivated.” Collaborative projects also helped him build communication and teamwork skills — attributes he believes are essential in both academia and industry.
Now pursuing an Honours degree in Statistics, Mantjiu has set his sights on a data-driven career in research, analytics, or education. “Eventually, I’d love to pursue a Master’s in biostatistics or data science. I want to work where research meets impact — especially in health or finance.”
When asked what advice he has for future students, his answer is clear: “Be ready to think hard, fail forward, and stay curious. Mathematical Science isn’t just about numbers; it’s about thinking clearly, solving problems, and making a difference.”
Mantjiu’s journey is a shining example of what South African youth can achieve with the right mindset, support, and sense of purpose. As he looks to the future, he carries with him not just academic accolades but a vision for how mathematical science can unlock real change in the world.
By Tumelo Moila
by Lorato | Jun 17, 2025 | Accolades and Achievements, All News, SMU Media, Student Media
by Lorato | Jun 11, 2025 | Accolades and Achievements, All News, SMU Media, Student Media
From Westonaria in Gauteng to the forefront of statistical innovation, SMU graduate and Senior Data Scientist at the FNB Retail Chief Data & Analytics Office (CDAO), Dr Sandile Johannes Butelezi, has achieved a remarkable milestone: earning a PhD in Statistics in just two years. He completed his doctorate with six published papers, three under review, and presentations at international conferences. His research, grounded in his professional experience within the insurance industry, presents a transformative approach to short-term insurance modelling in a world grappling with climate change and economic volatility.
Butelezi’s doctoral thesis, completed at a leading South African institution, centred on enhancing the accuracy and fairness of insurance risk models, particularly in the short-term motor insurance sector. “Working in the insurance sector revealed how outdated traditional models have become, especially in an era of unpredictable weather and shifting risk profiles,” he explained. “My goal was to contribute adaptive and equitable methods that reflect the complex realities we face.”
His solution was a hybrid modelling framework that blends generalised linear models (GLMs)—a mainstay of actuarial science—with advanced machine learning techniques such as XGBoost, gradient boosting machines, and random forests. Among these, XGBoost delivered the most promising results, achieving a robust R² of 0.68 when tested against real insurance claims data from 2021 to 2024, alongside simulated extreme-weather scenarios.
The model revealed significant regional and seasonal variations in claim patterns. Flood-related claims, for instance, peaked during summer months, while metropolitan areas like Gauteng recorded higher instances of malicious damage and motor accidents. These findings underscored the shortcomings of uniform premium pricing and pointed towards the need for dynamic, locally tailored strategies.
One of the study’s most striking findings was not statistical, but social: a concerning pattern of claim rejections among non-native English speakers, often due to misunderstandings of complex policy language. “This is not just a technical issue—it’s a matter of equity,” said Butelezi. “We need simplified, multilingual insurance documentation that’s accessible to all policyholders.”
The practical implications of Buthelezi’s research are profound. Insurers can use his model to more accurately price risk, allocate resources, and respond proactively to claims volatility. Regulators and policymakers, meanwhile, gain a tool for promoting a more resilient, inclusive, and climate-aware financial protection system.
Looking ahead, Butelezi sees exciting avenues for continued research. These include integrating high-resolution climate data for long-term forecasting, applying behavioural economics to understand consumer behaviour in insurance uptake, and advancing AI applications such as deep learning and reinforcement learning to manage high-dimensional or unstructured data sources like satellite imagery or text-based claims reports.
“There’s also urgent work to be done on the ethics of algorithmic decision-making,” he added. “We must ensure that data-driven models do not reinforce existing social and economic inequalities. Fairness must be an intentional part of model design.”
Completing a PhD in just two years is no small feat, and Buthelezi credits his success to disciplined time management and a strong support network of supervisors, family, and peers. “I set realistic goals, stuck to a structured routine, and allowed myself breaks when needed. But above all, the encouragement from my support system made the difference,” he said.
Now, Butelezi plans to continue bridging the gap between academia and practice. He hopes to supervise postgraduate students, contribute to academic research, and influence public policy in areas such as disaster risk management, bioinformatics, and AI regulation. He also remains committed to developing new theoretical frameworks in mathematical statistics.
His advice to aspiring statisticians is both grounded and aspirational: “Master the fundamentals, stay curious, and be unafraid of messy, real-world data. The world needs statisticians who are both technically sharp and socially conscious.”
Reflecting on his journey from Westonaria to international academic recognition, he summarised it with a simple yet powerful phrase: “Only the best is good enough.”
By Tumelo Moila
by Lorato | Jun 11, 2025 | Accolades and Achievements, All News, SMU Media, Student Media
History has been made at Sefako Makgatho Health Sciences University (SMU) as Dr Phumudzo Lloyd Seabe becomes the first-ever PhD graduate from the Department of Mathematics and Applied Mathematics. This achievement not only marks a significant academic milestone for the University but also represents a powerful personal journey, rooted in legacy, discipline, and a vision for inclusive technological advancement.
Born and raised in Gogobole, a village in Venda, Limpopo, Seabe was raised in a home shaped by women of strength and conviction. “I was raised in a household led by women of great dignity and discipline,” he says. “My mother’s consistency taught me the power of hard work. My grandmother—sharp-witted and deeply principled—was the compass of our family.”
His grandmother, a retired domestic worker from the South African Air Force Base, had a profound influence on him. As the second of twelve grandchildren, he was always under her watchful eye. Her passing in April 2020, just over a year before he started his PhD, left a significant void. Yet her spirit continued to guide him. “She used to say, ‘Noma kubuhlungu, kodwa kulungile’—Even though it hurts, it is well,” he recalls. “That became my silent prayer during long nights of research and writing.”
In July 2021, Seabe began his PhD journey at SMU with a clear and ambitious research focus: to combine the tools of artificial intelligence (AI), behavioural finance, and traditional investment theory to analyse the highly volatile cryptocurrency market.
His thesis, titled Advancing Cryptocurrency Market Analysis and Investment Strategies: An Integrated Approach Using Machine Learning, Sentiment Analysis, and Factor Investing, presents a comprehensive framework for understanding and forecasting cryptocurrency market behaviour. It integrates advanced deep learning models—including LSTM – Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Bi-Directional LSTM, and Temporal Attention Networks—with time series and sentiment data from over 48 million cryptocurrency-related tweets.
Using Natural Language Processing (NLP), he extracted real-time sentiment signals via Valence Aware Dictionary and sEntiment Reasoner (VADER) and RoBERTa, two of the leading sentiment analysis tools. These were integrated into hybrid models enhanced with SHapley Additive exPlanations (SHAP) explainability, allowing for transparency and interpretability of AI forecasts. In addition to technical innovation, Seabe revisited classical finance theories using Fama–MacBeth regressions and cross-sectional portfolio construction. His findings confirmed that even in digital, decentralised markets, traditional predictors like momentum and size continue to offer robust explanatory power.
His work resulted in four publications in DHET-accredited journals, including one paper cited over 140 times and nominated for the 2023 Best Paper Award, with the outcome to be announced in June 2025. These achievements underscore the global academic relevance and impact of his work.
Professor Maggie Aphane, Head of the Department of Mathematics and Applied Mathematics, praised this historic moment: “Dr Phumudzo Seabe has set a new record in the Department of Mathematics and Applied Mathematics by becoming the first PhD graduate from Medunsa, University of Limpopo (Medunsa Campus), and SMU. He successfully completed his PhD in an unprecedented timeframe. As Head of Department, it is a privilege for me to witness this achievement during my tenure. This accomplishment reflects my dedication to the university and the nation as a whole. I am committed to fostering the production of more PhD graduates.”
Seabe’s journey was not without sacrifice. Balancing full-time professional responsibilities alongside rigorous academic research required remarkable discipline and focus. “This journey was never just about research,” he says. “It was about honouring the sacrifices of my family, especially my grandmother and mother. Every model I built, every paper I wrote, was an offering to them.”
Now, as he graduates, Seabe continues to work at the intersection of financial intelligence, artificial intelligence, and behavioural insight. His vision is to build data-driven systems that are not only accurate but inclusive—technologies that reflect both innovation and the human condition. Seabe’s success is not only a personal victory but a beacon of possibility for rural communities and aspiring researchers across South Africa. He has not just earned a PhD—he has made history.
By Dimakatso Modise
The unveiling of the 1000-Bed Student Housing Project (Phase 1 of 2000 beds), the Revitalised Library, and the ICT Refresher Project reflects SMU’s bold new era: one driven by academic excellence, ethical leadership, and the dignity of student experience.